Induction of Progenitor Exhausted Tissue-Resident Memory CD8+ T Cells Upon Salmonella Typhi Porins Adjuvant Immunization Correlates With Melanoma Control and Anti-PD-1 Immunotherapy Cooperation

Induction of Progenitor Exhausted Tissue-Resident Memory CD8+ T Cells Upon Salmonella Typhi Porins Adjuvant Immunization Correlates With Melanoma Control and Anti-PD-1 Immunotherapy Cooperation

Immunotherapy has improved the clinical response in melanoma patients, although a relevant percentage of patients still cannot be salvaged. The search for the immune populations that provide the best tumor control and that can be coaxed by immunotherapy strategies is a hot topic in cancer research n...

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Bibliographic Details
Main Authors: Ricardo A. León-Letelier, Daniel I. Castro-Medina, Oscar Badillo-Godinez, Araceli Tepale-Segura, Enrique Huanosta-Murillo, Cristina Aguilar-Flores, Saraí G. De León-Rodríguez, Alejandra Mantilla, Ezequiel M. Fuentes-Pananá, Constantino López-Macías, Laura C. Bonifaz
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Immunology
Subjects:
melanoma
immunotherapy
adjuvant
tissue-resident memory T cells
progenitor exhausted T cells
anti-PD-1 Ab
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2020.583382/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2020.583382/full

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