Treatment with metformin in twelve patients with Lafora disease

Treatment with metformin in twelve patients with Lafora disease

Abstract Background Lafora disease (LD) is a rare, lethal, progressive myoclonus epilepsy for which no targeted therapy is currently available. Studies on a mouse model of LD showed a good response to metformin, a drug with a well known neuroprotective effect. For this reason, in 2016, the European...

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Bibliographic Details
Main Authors: Francesca Bisulli, Lorenzo Muccioli, Giuseppe d’Orsi, Laura Canafoglia, Elena Freri, Laura Licchetta, Barbara Mostacci, Patrizia Riguzzi, Federica Pondrelli, Carlo Avolio, Tommaso Martino, Roberto Michelucci, Paolo Tinuper
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Orphanet Journal of Rare Diseases
Subjects:
Metformin
Lafora disease
Progressive myoclonus epilepsy
EPM2A
EPM2B
NHLRC1
Online Access:http://link.springer.com/article/10.1186/s13023-019-1132-3

Internet

http://link.springer.com/article/10.1186/s13023-019-1132-3

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