Self-Recognition Sensitizes Mouse and Human Regulatory T Cells to Low-Dose CD28 Superagonist Stimulation

Self-Recognition Sensitizes Mouse and Human Regulatory T Cells to Low-Dose CD28 Superagonist Stimulation

In rodents, low doses of CD28-specific superagonistic monoclonal antibodies (CD28 superagonists, CD28SA) selectively activate regulatory T cells (Treg). This observation has recently been extended to humans, suggesting an option for the treatment of autoimmune and inflammatory diseases. However, a m...

Full description

Bibliographic Details
Main Authors: Daniela Langenhorst, Paula Tabares, Tobias Gulde, Bryan R. Becklund, Susanne Berr, Charles D. Surh, Niklas Beyersdorf, Thomas Hünig
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
regulatory T cells
self-reactivity
autoimmunity
CD28 superagonists
TGN1412
TAB08
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01985/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01985/full

Similar Items