Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells

Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells

Elevated expression levels of eukaryotic initiation factor 4E (eIF4E) promote cancer development and progression. MAP kinase interacting kinases (MNKs) modulate the function of eIF4E through the phosphorylation that is necessary for oncogenic transformation. Therefore, pharmacologic MNK inhibitors m...

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Bibliographic Details
Main Authors: Eva M García-Recio, Celia Pinto-Díez, M Isabel Pérez-Morgado, Marta García-Hernández, Gerónimo Fernández, M Elena Martín, Víctor M González
Format: Article
Language:English
Published: Elsevier 2016-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
aptamer
cancer
MNK1
SELEX
translation
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300117

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http://www.sciencedirect.com/science/article/pii/S2162253116300117

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