Elevated phosphorylation of EGFR in NSCLC due to mutations in PTPRH.

Elevated phosphorylation of EGFR in NSCLC due to mutations in PTPRH.

The role of EGFR in lung cancer is well described with numerous activating mutations that result in phosphorylation and tyrosine kinase inhibitors that target EGFR. While the role of the EGFR kinase in non-small cell lung cancer (NSCLC) is appreciated, control of EGFR signaling pathways through deph...

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Bibliographic Details
Main Authors: Matthew R Swiatnicki, Jonathan P Rennhack, Mylena M O Ortiz, Daniel P Hollern, Ashlee V Perry, Rachel Kubiak, Sarai M Riveria Riveria, Sandra O'Reilly, Eran R Andrechek
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-09-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010362

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https://doi.org/10.1371/journal.pgen.1010362

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