Properdin inhibition ameliorates hepatic ischemia/reperfusion injury without interfering with liver regeneration in mice

Properdin inhibition ameliorates hepatic ischemia/reperfusion injury without interfering with liver regeneration in mice

Hepatic ischemia/reperfusion injury (IRI) often causes serious complications in liver surgeries, including transplantation. Complement activation seems to be involved in hepatic IRI; however, no complement-targeted intervention has been clinically applied. We investigated the therapeutic potential o...

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Bibliographic Details
Main Authors: Jiro Kusakabe, Koichiro Hata, Tetsuya Tajima, Hidetaka Miyauchi, Xiangdong Zhao, Shoichi Kageyama, Tatsuaki Tsuruyama, Etsuro Hatano
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
hepatic ischemia/reperfusion injury
liver transplantation
hepatectomy
complement
alternative pathway
properdin
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1174243/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1174243/full

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