Type 1 Diabetes Mellitus and the First Trimester Placenta: Hyperglycemia-Induced Effects on Trophoblast Proliferation, Cell Cycle Regulators, and Invasion

Type 1 Diabetes Mellitus and the First Trimester Placenta: Hyperglycemia-Induced Effects on Trophoblast Proliferation, Cell Cycle Regulators, and Invasion

Type 1 diabetes mellitus (T1DM) is associated with reduced fetal growth in early pregnancy, but a contributing role of the placenta has remained elusive. Thus, we investigated whether T1DM alters placental development in the first trimester. Using a protein array, the level of 60 cell-cycle-related...

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Bibliographic Details
Main Authors: Alejandro Majali-Martinez, Ursula Weiss-Fuchs, Heidi Miedl, Desiree Forstner, Julia Bandres-Meriz, Denise Hoch, Josip Djelmis, Marina Ivanisevic, Ursula Hiden, Martin Gauster, Gernot Desoye
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
diabetes
glucose
human trophoblasts
early pregnancy
Online Access:https://www.mdpi.com/1422-0067/22/20/10989

Internet

https://www.mdpi.com/1422-0067/22/20/10989

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