Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes

Imprinted Grb10, encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor (Igf1r) and insulin receptor (Insr) genes

Abstract Background Optimal size at birth dictates perinatal survival and long-term risk of developing common disorders such as obesity, type 2 diabetes and cardiovascular disease. The imprinted Grb10 gene encodes a signalling adaptor protein capable of inhibiting receptor tyrosine kinases, includin...

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Bibliographic Details
Main Authors: Kim Moorwood, Florentia M. Smith, Alastair S. Garfield, Andrew Ward
Format: Article
Language:English
Published: BMC 2024-05-01
Series:BMC Biology
Subjects:
Cell signalling
Developmental biology
Epistasis
Fetal growth
Genomic imprinting
Insulin
Online Access:https://doi.org/10.1186/s12915-024-01926-w

Internet

https://doi.org/10.1186/s12915-024-01926-w

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