DCLK1 Suppresses Tumor-Specific Cytotoxic T Lymphocyte Function Through Recruitment of MDSCs via the CXCL1-CXCR2 AxisSummary

DCLK1 Suppresses Tumor-Specific Cytotoxic T Lymphocyte Function Through Recruitment of MDSCs via the CXCL1-CXCR2 AxisSummary

Background & Aims: Gastrointestinal cancer stem cell marker doublecortin-like kinase (DCLK1) is strongly associated with poor outcomes in colorectal cancer (CRC). Although DCLK1’s regulatory effect on the tumor immune microenvironment has been hypothesized, its mode of action has not been sh...

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Bibliographic Details
Main Authors: Rui Yan, Jianjian Li, Zeru Xiao, Xiaona Fan, Heshu Liu, Ying Xu, Ruya Sun, Jian Liu, Jiannan Yao, Guangyu An, Yan Shi, Yang Ge
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
DCLK1
Colorectal Carcinoma
Tumor Microenvironment
Immune Escape
MDSCs
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X22002247

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http://www.sciencedirect.com/science/article/pii/S2352345X22002247

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