Host-Cell Type Dependent Features of Recombinant Human Aquaporin-4 Orthogonal Arrays of Particles—New Insights for Structural and Functional Studies

Host-Cell Type Dependent Features of Recombinant Human Aquaporin-4 Orthogonal Arrays of Particles—New Insights for Structural and Functional Studies

The CNS plasma-membrane water channel aquaporin-4 (AQP4) is expressed as two major isoforms able to aggregate into supramolecular assemblies known as ‘orthogonal arrays of particles’ (OAPs). OAP subnanometric features are largely unknown mainly because a method for the expression...

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Bibliographic Details
Main Authors: Francesco Pisani, Laura Simone, Maria Grazia Mola, Manuela De Bellis, Maria Mastrapasqua, Maddalena Ruggieri, Maria Trojano, Grazia Paola Nicchia, Maria Svelto, Antonio Frigeri
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cells
Subjects:
aquaporin-4
OAPs isolation
OAPs structure
neuromyelitis optica
Online Access:https://www.mdpi.com/2073-4409/8/2/119

Internet

https://www.mdpi.com/2073-4409/8/2/119

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