Methodological challenges in constructing DNA methylation risk scores

Polygenic approaches often access more variance of complex traits than is possible by single variant approaches. For genotype data, genetic risk scores (GRS) are widely used for risk prediction as well as in association and interaction studies. Recently, interest has been growing in transferring GRS...

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Bibliographic Details
Main Authors: Anke Hüls, Darina Czamara
Format: Article
Language:English
Published: Taylor & Francis Group 2020-02-01
Series:Epigenetics
Subjects:
Online Access:http://dx.doi.org/10.1080/15592294.2019.1644879