Neurofibromin Deficiency Causes Epidermal Growth Factor Receptor Upregulation through the Activation of Ras/ERK/SP1 Signaling Pathway in Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheet Tumor

Neurofibromin Deficiency Causes Epidermal Growth Factor Receptor Upregulation through the Activation of Ras/ERK/SP1 Signaling Pathway in Neurofibromatosis Type 1-Associated Malignant Peripheral Nerve Sheet Tumor

Neurofibromatosis type 1 (NF1) is an autosomal dominant human genetic disorder. The progression of benign plexiform neurofibromas to malignant peripheral nerve sheet tumors (MPNSTs) is a major cause of mortality in patients with NF1. Although elevated epidermal growth factor receptor (EGFR) expressi...

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Bibliographic Details
Main Authors: Gun-Hoo Park, Su-Jin Lee, Chang-Gun Lee, Jeonghyun Kim, Eunkuk Park, Seon-Yong Jeong
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
neurofibromatosis type 1 (NF1)
neurofibromin
EGFR
malignant peripheral nerve sheet tumor (MPNST)
sarcoma
tumor progression
Online Access:https://www.mdpi.com/1422-0067/22/24/13308

Internet

https://www.mdpi.com/1422-0067/22/24/13308

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