Comparative Evaluation of the Asymmetric Synthesis of (S)-Norlaudanosoline in a Two-Step Biocatalytic Reaction with Whole <i>Escherichia coli</i> Cells in Batch and Continuous Flow Catalysis

Comparative Evaluation of the Asymmetric Synthesis of (S)-Norlaudanosoline in a Two-Step Biocatalytic Reaction with Whole <i>Escherichia coli</i> Cells in Batch and Continuous Flow Catalysis

Opioids are important analgesics, and their pharmaceutical application is increasing worldwide. Many opioids are based on benzylisoquinoline alkaloids (BIA) and are still industrially produced from <i>Papaver somniferum</i> (opium poppy). (S)-norlaudanosoline ((S)-NLS) is a complex BIA a...

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Bibliographic Details
Main Authors: Adson Hagen Arnold, Kathrin Castiglione
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Catalysts
Subjects:
chiral synthesis
flow-reactor
immobilized cells
dopamine
stereolithography
transaminase
Online Access:https://www.mdpi.com/2073-4344/13/10/1347

Internet

https://www.mdpi.com/2073-4344/13/10/1347

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