Biodegradable MnO2-based gene-engineered nanocomposites for chemodynamic therapy and enhanced antitumor immunity
Immune checkpoint blockade (ICB) is emerging as a promising therapeutic approach for clinical treatment against various cancers. However, ICB based monotherapies still suffer from low immune response rate due to the limited and exhausted tumor-infiltrating lymphocytes as well as tumor immunosuppress...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006422003295 |
| _version_ | 1797938056771141632 |
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| author | Yiru Wang Ming Wu Xiaorong Wang Peiyuan Wang Zhaoyu Ning Yongyi Zeng Xiaolong Liu Haiyan Sun Aixian Zheng |
| author_facet | Yiru Wang Ming Wu Xiaorong Wang Peiyuan Wang Zhaoyu Ning Yongyi Zeng Xiaolong Liu Haiyan Sun Aixian Zheng |
| author_sort | Yiru Wang |
| collection | DOAJ |
| description | Immune checkpoint blockade (ICB) is emerging as a promising therapeutic approach for clinical treatment against various cancers. However, ICB based monotherapies still suffer from low immune response rate due to the limited and exhausted tumor-infiltrating lymphocytes as well as tumor immunosuppressive microenvironment. In this work, the cell membrane with surface displaying PD-1 proteins (PD1-CM) was prepared for immune checkpoint blockade, which was further combined with multifunctional and biodegradable MnO2 for systematic and robust antitumor therapy. The MnO2-based gene-engineered nanocomposites can catalyze the decomposition of abundant H2O2 in TME to generate O2, which can promote the intratumoral infiltration of T cells, and thus improve the effect of immune checkpoint blockade by PD-1 proteins on PD1-CM. Furthermore, MnO2 in the nanocomposites can be completely degraded into Mn2+, which can catalyze the generation of highly toxic hydroxyl radicals for chemodynamic therapy, thereby further enhancing the therapeutic effect. In addition, the prepared nanocomposites possess the advantages of low cost, easy preparation and good biocompatibility, which are expected to become promising agents for combination immunotherapy. |
| first_indexed | 2024-04-10T18:54:46Z |
| format | Article |
| id | doaj.art-804db2fbb8e34e0bb66f8b6eb9a24eba |
| institution | Directory Open Access Journal |
| issn | 2590-0064 |
| language | English |
| last_indexed | 2024-04-10T18:54:46Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj.art-804db2fbb8e34e0bb66f8b6eb9a24eba2023-02-01T04:27:24ZengElsevierMaterials Today Bio2590-00642023-02-0118100531Biodegradable MnO2-based gene-engineered nanocomposites for chemodynamic therapy and enhanced antitumor immunityYiru Wang0Ming Wu1Xiaorong Wang2Peiyuan Wang3Zhaoyu Ning4Yongyi Zeng5Xiaolong Liu6Haiyan Sun7Aixian Zheng8The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, PR China; College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, PR ChinaThe United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, PR ChinaThe United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, PR China; College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, PR ChinaKey Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, PR ChinaThe United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, PR China; College of Biological Science and Engineering, Fuzhou University, Fuzhou, 350116, PR ChinaThe United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, PR ChinaThe United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, PR China; Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, PR ChinaDepartment of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, PR China; Corresponding author.The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou, 350025, PR China; Corresponding author.Immune checkpoint blockade (ICB) is emerging as a promising therapeutic approach for clinical treatment against various cancers. However, ICB based monotherapies still suffer from low immune response rate due to the limited and exhausted tumor-infiltrating lymphocytes as well as tumor immunosuppressive microenvironment. In this work, the cell membrane with surface displaying PD-1 proteins (PD1-CM) was prepared for immune checkpoint blockade, which was further combined with multifunctional and biodegradable MnO2 for systematic and robust antitumor therapy. The MnO2-based gene-engineered nanocomposites can catalyze the decomposition of abundant H2O2 in TME to generate O2, which can promote the intratumoral infiltration of T cells, and thus improve the effect of immune checkpoint blockade by PD-1 proteins on PD1-CM. Furthermore, MnO2 in the nanocomposites can be completely degraded into Mn2+, which can catalyze the generation of highly toxic hydroxyl radicals for chemodynamic therapy, thereby further enhancing the therapeutic effect. In addition, the prepared nanocomposites possess the advantages of low cost, easy preparation and good biocompatibility, which are expected to become promising agents for combination immunotherapy.http://www.sciencedirect.com/science/article/pii/S2590006422003295Cell membranePD-1Immune checkpoint blockadeMnO2HypoxiaChemodynamic therapy |
| spellingShingle | Yiru Wang Ming Wu Xiaorong Wang Peiyuan Wang Zhaoyu Ning Yongyi Zeng Xiaolong Liu Haiyan Sun Aixian Zheng Biodegradable MnO2-based gene-engineered nanocomposites for chemodynamic therapy and enhanced antitumor immunity Materials Today Bio Cell membrane PD-1 Immune checkpoint blockade MnO2 Hypoxia Chemodynamic therapy |
| title | Biodegradable MnO2-based gene-engineered nanocomposites for chemodynamic therapy and enhanced antitumor immunity |
| title_full | Biodegradable MnO2-based gene-engineered nanocomposites for chemodynamic therapy and enhanced antitumor immunity |
| title_fullStr | Biodegradable MnO2-based gene-engineered nanocomposites for chemodynamic therapy and enhanced antitumor immunity |
| title_full_unstemmed | Biodegradable MnO2-based gene-engineered nanocomposites for chemodynamic therapy and enhanced antitumor immunity |
| title_short | Biodegradable MnO2-based gene-engineered nanocomposites for chemodynamic therapy and enhanced antitumor immunity |
| title_sort | biodegradable mno2 based gene engineered nanocomposites for chemodynamic therapy and enhanced antitumor immunity |
| topic | Cell membrane PD-1 Immune checkpoint blockade MnO2 Hypoxia Chemodynamic therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2590006422003295 |
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