Ras signaling and RREB1 are required for the dissociation of medial edge epithelial cells in murine palatogenesis

Ras signaling and RREB1 are required for the dissociation of medial edge epithelial cells in murine palatogenesis

Cleft palate is one of the major congenital craniofacial birth defects. The etiology underlying the pathogenesis of cleft palate has yet to be fully elucidated. Dissociation of the medial edge epithelium (MEE) at the contacting region of palatal shelves and subsequent migration or apoptosis of MEE c...

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Bibliographic Details
Main Authors: Toshihiro Inubushi, Ayaka Fujiwara, Takumi Hirose, Gozo Aoyama, Toshihiro Uchihashi, Naoki Yoshida, Yuki Shiraishi, Yu Usami, Hiroshi Kurosaka, Satoru Toyosawa, Susumu Tanaka, Tetsuro Watabe, Mikihiko Kogo, Takashi Yamashiro
Format: Article
Language:English
Published: The Company of Biologists 2022-02-01
Series:Disease Models & Mechanisms
Subjects:
ras
rreb1
medial edge epithelial cells
emt
tgf-β3
palatogenesis
Online Access:http://dmm.biologists.org/content/15/2/dmm049093

Internet

http://dmm.biologists.org/content/15/2/dmm049093

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