Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions

Progranulin Deficiency Induces Mitochondrial Dysfunction in Frontotemporal Lobar Degeneration with TDP-43 Inclusions

Loss-of-function (LOF) mutations in <i>GRN</i> gene, which encodes progranulin (PGRN), cause frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP). FTLD-TDP is one of the most common forms of early onset dementia, but its pathogenesis is not fully understood. Mitochondrial...

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Bibliographic Details
Main Authors: Guiomar Rodríguez-Periñán, Ana de la Encarnación, Fermín Moreno, Adolfo López de Munain, Ana Martínez, Ángeles Martín-Requero, Carolina Alquézar, Fernando Bartolomé
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Antioxidants
Subjects:
progranulin
FTLD-TDP
mitochondria
bioenergetics
mitophagy
autophagy
Online Access:https://www.mdpi.com/2076-3921/12/3/581

Internet

https://www.mdpi.com/2076-3921/12/3/581

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