Preparation and Evaluation of Amino Acid Conjugates of Celecoxib as Prodrugs to Improve the Pharmacokinetic and Therapeutic Properties of Celecoxib

Preparation and Evaluation of Amino Acid Conjugates of Celecoxib as Prodrugs to Improve the Pharmacokinetic and Therapeutic Properties of Celecoxib

Although celecoxib is quite effective in the management of inflammation-related diseases, especially arthritis, its use is limited by concerns including low bioavailability (BA), non-linear pharmacokinetic (PK) profile, and peak concentration-related toxicity. To overcome these issues, we designed a...

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Bibliographic Details
Main Authors: Yonghyun Lee, Jungyun Kim, Wooseong Kim, In-Soo Yoon, Yunjin Jung
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Pharmaceutics
Subjects:
celecoxib
prodrug
bioavailability
PK linearity
extended absorption
carrageenan-induced rat paw edema model
Online Access:https://www.mdpi.com/1999-4923/12/11/1043

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https://www.mdpi.com/1999-4923/12/11/1043

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