DYRK2 downregulation in colorectal cancer leads to epithelial–mesenchymal transition induction and chemoresistance

Abstract Colorectal cancer (CRC) is among the most prominent causes of cancer-associated mortality in the world, with chemoresistance representing one of the leading causes of treatment failure. However, the mechanisms governing such chemoresistance remain incompletely understood. In this study, the...

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Bibliographic Details
Main Authors: Chunrong Wu, Guiyin Sun, Fan Wang, Jiangyan Chen, Fangbiao Zhan, Xiaojuan Lian, Jie Wang, Fanbin Weng, Bo Li, Weijun Tang, Jin Quan, Debing Xiang
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-25053-0