Pfit is a structurally novel Crohn's disease-associated superantigen.

Pfit is a structurally novel Crohn's disease-associated superantigen.

T cell responses to enteric bacteria are important in inflammatory bowel disease. I2, encoded by the pfiT gene of Pseudomonas fluorescens, is a T-cell superantigen associated with human Crohn's disease. Here we report the crystal structure of pfiT at 1.7Å resolution and provide a functional ana...

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Bibliographic Details
Main Authors: Lihui Liu, Hui Chen, Matthew B Brecher, Zhong Li, Bo Wei, Bisweswar Nandi, Jing Zhang, Hua Ling, Gary Winslow, Jonathan Braun, Hongmin Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3873459?pdf=render

Internet

http://europepmc.org/articles/PMC3873459?pdf=render

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