Role of hepatocyte nuclear factor 4 alpha in cell proliferation and gemcitabine resistance in pancreatic adenocarcinoma

Role of hepatocyte nuclear factor 4 alpha in cell proliferation and gemcitabine resistance in pancreatic adenocarcinoma

Abstract Background Hepatocyte nuclear factor 4α (HNF4α) is a tissue-specific transcription factor that regulates the expression of numerous genes in hepatocytes and pancreatic β cells. HNF4α has been reported to affect cell proliferation and chemoresistance in several cancers. However, the role of...

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Bibliographic Details
Main Authors: Qiqing Sun, Wenyan Xu, Shunrong Ji, Yi Qin, Wensheng Liu, Qiangsheng Hu, Zheng Zhang, Mengqi Liu, Xianjun Yu, Xiaowu Xu
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Cancer Cell International
Subjects:
Pancreatic adenocarcinoma
Hepatocyte nuclear factor 4α
Human equilibrative nucleoside transporter 1
Proliferation
Gemcitabine resistance
Online Access:http://link.springer.com/article/10.1186/s12935-019-0767-4

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http://link.springer.com/article/10.1186/s12935-019-0767-4

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