Inhibition of Neovascularization and Tumor Growth, Facilitation of Wound Repair, by Halofuginone, an Inhibitor of Collagen Type I Synthesis

Inhibition of Neovascularization and Tumor Growth, Facilitation of Wound Repair, by Halofuginone, an Inhibitor of Collagen Type I Synthesis

Halofuginone, an inhibitor of collagen α1(I) gene expression was used for the treatment of subcutaneously implanted C6 glioma tumors. Halofuginone had no effect on the growth of C6 glioma spheroids in vitro, these spheroids showed no collagen α1(I) expression and no collagen synthesis. However, a si...

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Bibliographic Details
Main Authors: Rinat Abramovitch, Hagit Dafni, Michal Neeman, Amon Nagler, Mark Pines
Format: Article
Language:English
Published: Elsevier 1999-10-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
halofuginone
C6 glioma
Collagen type I
MRI
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558699800232

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