Extracting interpretable features for pathologists using weakly supervised learning to predict p16 expression in oropharyngeal cancer

Abstract One drawback of existing artificial intelligence (AI)-based histopathological prediction models is the lack of interpretability. The objective of this study is to extract p16-positive oropharyngeal squamous cell carcinoma (OPSCC) features in a form that can be interpreted by pathologists us...

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Bibliographic Details
Main Authors: Masahiro Adachi, Tetsuro Taki, Naoya Sakamoto, Motohiro Kojima, Akihiko Hirao, Kazuto Matsuura, Ryuichi Hayashi, Keiji Tabuchi, Shumpei Ishikawa, Genichiro Ishii, Shingo Sakashita
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-55288-y