Selecting surfactants for the maximum inhibition of the activity of the multidrug resistance efflux pump transporter, P-glycoprotein: conceptual development
Amphiphilic excipients, such as surfactants, have been shown to be inhibitors of the multidrug resistance (MDR) efflux pump transporter protein, P glycoprotein (Pgp). In vitro studies using many surfactants have demonstrated that those with an optimum hydrophilic-lipophilic balance (HLB) exhibit gre...
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| Format: | Article |
| Language: | English |
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International Pharmaceutical Excipients Council
2016-11-01
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| Series: | Journal of Excipients and Food Chemicals |
| Online Access: | https://jefc.scholasticahq.com/article/1133-selecting-surfactants-for-the-maximum-inhibition-of-the-activity-of-the-multidrug-resistance-efflux-pump-transporter-p-glycoprotein-conceptual-devel |