New insights into the regulation of Cystathionine beta synthase (CBS), an enzyme involved in intellectual deficiency in Down syndrome

New insights into the regulation of Cystathionine beta synthase (CBS), an enzyme involved in intellectual deficiency in Down syndrome

Down syndrome (DS), the most frequent chromosomic aberration, results from the presence of an extra copy of chromosome 21. The identification of genes which overexpression contributes to intellectual disability (ID) in DS is important to understand the pathophysiological mechanisms involved and deve...

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Bibliographic Details
Main Authors: Pierre Conan, Alice Léon, Noéline Caroff, Claire Rollet, Loubna Chaïr, Jennifer Martin, Frédéric Bihel, Olivier Mignen, Cécile Voisset, Gaëlle Friocourt
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Neuroscience
Subjects:
CBS
DYRK1A
GSK3β
Akt
NF-κB
pharmacological inhibitor
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.1110163/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2022.1110163/full

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