Protein conformational transitions explored by a morphing approach based on normal mode analysis in internal coordinates

Large-scale conformational changes are essential for proteins to function properly. Given that these transition events rarely occur, however, it is challenging to comprehend their underlying mechanisms through experimental and theoretical approaches. In this study, we propose a new computational met...

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Bibliographic Details
Main Authors: Byung Ho Lee, Soon Woo Park, Soojin Jo, Moon Ki Kim
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568156/?tool=EBI