A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop

A structural exposé of noncanonical molecular reactivity within the protein tyrosine phosphatase WPD loop

Inositol pyrophosphates (PP-IPs) regulate immunity and phosphate homeostasis. Here, the authors’ structural dissection of an Arabidopsis thaliana PP-IP phosphatase reveals that substrates drive their own hydrolysis and identifies a highly elusive metaphosphate-like reaction intermediate.

Bibliographic Details
Main Authors: Huanchen Wang, Lalith Perera, Nikolaus Jork, Guangning Zong, Andrew M. Riley, Barry V. L. Potter, Henning J. Jessen, Stephen B. Shears
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29673-y

Internet

https://doi.org/10.1038/s41467-022-29673-y

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