Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR

Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR

DNA damage response (DDR) is a highly conserved genome surveillance mechanism that preserves cell viability in the presence of chemotherapeutic drugs. Hence, small molecules that inhibit DDR are expected to enhance the anti-cancer effect of chemotherapy. Through a recent chemical library screen, we...

Full description

Bibliographic Details
Main Authors: Fangfang Wang, Sora Jin, Franklin Mayca Pozo, Danmei Tian, Xiyang Tang, Yi Dai, Xinsheng Yao, Jinshan Tang, Youwei Zhang
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Chemical screen
Shikonin
DNA damage Response
ATM
ATR
ATRIP
Online Access:http://www.sciencedirect.com/science/article/pii/S221138352100335X

Internet

http://www.sciencedirect.com/science/article/pii/S221138352100335X

Similar Items