Immunotherapies: The Blockade of Inhibitory Signals

<p>T lymphocytes require signaling by the T cell receptor and by nonclonotypic cosignaling receptors. The costimulatory and inhibitory signals profoundly influence the course of immune responses by amplifying or reducing the transcriptional effects of T cell receptor triggering. The inhibitory...

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Bibliographic Details
Main Author: Yan-Ling Wu, Jing Liang, Wen Zhang, Yoshimasa Tanaka, Hiroshi Sugiyama
Format: Article
Language:English
Published: Ivyspring International Publisher 2012-01-01
Series:International Journal of Biological Sciences
Online Access:http://www.biolsci.org/v08p1420.htm