Immunotherapies: The Blockade of Inhibitory Signals
<p>T lymphocytes require signaling by the T cell receptor and by nonclonotypic cosignaling receptors. The costimulatory and inhibitory signals profoundly influence the course of immune responses by amplifying or reducing the transcriptional effects of T cell receptor triggering. The inhibitory...
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| Format: | Article |
| Language: | English |
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Ivyspring International Publisher
2012-01-01
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| Series: | International Journal of Biological Sciences |
| Online Access: | http://www.biolsci.org/v08p1420.htm |
| _version_ | 1811289820224290816 |
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| author | Yan-Ling Wu, Jing Liang, Wen Zhang, Yoshimasa Tanaka, Hiroshi Sugiyama |
| author_facet | Yan-Ling Wu, Jing Liang, Wen Zhang, Yoshimasa Tanaka, Hiroshi Sugiyama |
| author_sort | Yan-Ling Wu, Jing Liang, Wen Zhang, Yoshimasa Tanaka, Hiroshi Sugiyama |
| collection | DOAJ |
| description | <p>T lymphocytes require signaling by the T cell receptor and by nonclonotypic cosignaling receptors. The costimulatory and inhibitory signals profoundly influence the course of immune responses by amplifying or reducing the transcriptional effects of T cell receptor triggering. The inhibitory receptors such as CTLA-4, PD-1, and BTLA have recently drawn much attention as potential targets for immunotherapies. This review focuses on the progress that has been made with the mentioned receptors in the field of immunotherapies for autoimmune diseases, malignancies, infectious diseases, and transplantation.</p> |
| first_indexed | 2024-04-13T04:01:05Z |
| format | Article |
| id | doaj.art-8072fa703a8f44afb378eea9292840fd |
| institution | Directory Open Access Journal |
| issn | 1449-2288 |
| language | English |
| last_indexed | 2024-04-13T04:01:05Z |
| publishDate | 2012-01-01 |
| publisher | Ivyspring International Publisher |
| record_format | Article |
| series | International Journal of Biological Sciences |
| spelling | doaj.art-8072fa703a8f44afb378eea9292840fd2022-12-22T03:03:28ZengIvyspring International PublisherInternational Journal of Biological Sciences1449-22882012-01-0181014201430Immunotherapies: The Blockade of Inhibitory SignalsYan-Ling Wu, Jing Liang, Wen Zhang, Yoshimasa Tanaka, Hiroshi Sugiyama<p>T lymphocytes require signaling by the T cell receptor and by nonclonotypic cosignaling receptors. The costimulatory and inhibitory signals profoundly influence the course of immune responses by amplifying or reducing the transcriptional effects of T cell receptor triggering. The inhibitory receptors such as CTLA-4, PD-1, and BTLA have recently drawn much attention as potential targets for immunotherapies. This review focuses on the progress that has been made with the mentioned receptors in the field of immunotherapies for autoimmune diseases, malignancies, infectious diseases, and transplantation.</p>http://www.biolsci.org/v08p1420.htm |
| spellingShingle | Yan-Ling Wu, Jing Liang, Wen Zhang, Yoshimasa Tanaka, Hiroshi Sugiyama Immunotherapies: The Blockade of Inhibitory Signals International Journal of Biological Sciences |
| title | Immunotherapies: The Blockade of Inhibitory Signals |
| title_full | Immunotherapies: The Blockade of Inhibitory Signals |
| title_fullStr | Immunotherapies: The Blockade of Inhibitory Signals |
| title_full_unstemmed | Immunotherapies: The Blockade of Inhibitory Signals |
| title_short | Immunotherapies: The Blockade of Inhibitory Signals |
| title_sort | immunotherapies the blockade of inhibitory signals |
| url | http://www.biolsci.org/v08p1420.htm |
| work_keys_str_mv | AT yanlingwujingliangwenzhangyoshimasatanakahiroshisugiyama immunotherapiestheblockadeofinhibitorysignals |