Design, synthesis, and cytotoxic activity of 2-amino-1,4-naphthoquinone-benzamide derivatives as apoptosis inducers

Design, synthesis, and cytotoxic activity of 2-amino-1,4-naphthoquinone-benzamide derivatives as apoptosis inducers

Abstract A new series of 2-amino-1,4-naphthoquinone-benzamides 5a-n was designed based on previously reported potent cytotoxic agents. These compounds were synthesized from the reaction of 1,4-naphthoquinone, 4-aminobenzoic acid, and appropriate amine derivatives in good yields. Cytotoxic activities...

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Bibliographic Details
Main Authors: Mohammad Hosein Sayahi, Bahareh Hassani, Maryam Mohammadi-Khanaposhtani, Navid Dastyafteh, Mohammad Reza Gohari, Mohammadreza Mohajeri Tehrani, Bagher Larijani, Mohammad Mahdavi, Omidreza Firuzi
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
2-Amino-1,4-naphthoquinon
Benzamide
Apoptosis
Cytotoxic
Online Access:https://doi.org/10.1038/s41598-024-78468-2

Internet

https://doi.org/10.1038/s41598-024-78468-2

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