Time-resolved β-lactam cleavage by L1 metallo-β-lactamase

Time-resolved β-lactam cleavage by L1 metallo-β-lactamase

Metallo-β-lactamases cleave β-lactam moiety of many broadly used antibiotics. Here the authors captured mechanistic details of the enzyme catalyzed reaction using time-resolved xray synchrotron serial crystallography.

Bibliographic Details
Main Authors: M. Wilamowski, D. A. Sherrell, Y. Kim, A. Lavens, R. W. Henning, K. Lazarski, A. Shigemoto, M. Endres, N. Maltseva, G. Babnigg, S. C. Burdette, V. Srajer, A. Joachimiak
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35029-3

Internet

https://doi.org/10.1038/s41467-022-35029-3

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