Analysis of chromosomal structural variations in patients with recurrent spontaneous abortion using optical genome mapping

Analysis of chromosomal structural variations in patients with recurrent spontaneous abortion using optical genome mapping

Background and aims: Certain chromosomal structural variations (SVs) in biological parents can lead to recurrent spontaneous abortions (RSAs). Unequal crossing over during meiosis can result in the unbalanced rearrangement of gamete chromosomes such as duplication or deletion. Unfortunately, routine...

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Bibliographic Details
Main Authors: Huihua Rao, Haoyi Zhang, Yongyi Zou, Pengpeng Ma, Tingting Huang, Huizhen Yuan, Jihui Zhou, Wan Lu, Qiao Li, Shuhui Huang, Yanqiu Liu, Bicheng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Genetics
Subjects:
recurrent spontaneous abortion (RSA)
structural variations (SVs)
optical genome mapping (OGM)
Oxford Nanopore technology (ONT)
balanced reciprocal translocation (BRT)
complex chromosomal rearrangement (CCR)
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2023.1248755/full

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https://www.frontiersin.org/articles/10.3389/fgene.2023.1248755/full

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