Antiproliferative Fate of the Tetraploid Formed after Mitotic Slippage and Its Promotion; A Novel Target for Cancer Therapy Based on Microtubule Poisons

Antiproliferative Fate of the Tetraploid Formed after Mitotic Slippage and Its Promotion; A Novel Target for Cancer Therapy Based on Microtubule Poisons

Microtubule poisons inhibit spindle function, leading to activation of spindle assembly checkpoint (SAC) and mitotic arrest. Cell death occurring in prolonged mitosis is the first target of microtubule poisons in cancer therapies. However, even in the presence of microtubule poisons, SAC and mitotic...

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Bibliographic Details
Main Authors: Yuji Nakayama, Toshiaki Inoue
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:Molecules
Subjects:
spindle assembly checkpoint
cell death during mitotic arrest
mitotic slippage
mitotic catastrophe
tetraploid
antiproliferative fate
chemoresistance
basal autophagy
micronuclei
clustered micronuclei
Online Access:http://www.mdpi.com/1420-3049/21/5/663

Internet

http://www.mdpi.com/1420-3049/21/5/663

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