Cisplatin protects mice from challenge of Cryptococcus neoformans by targeting the Prp8 intein

Cisplatin protects mice from challenge of Cryptococcus neoformans by targeting the Prp8 intein

ABSTRACTThe Prp8 intein is one of the most widespread eukaryotic inteins, present in important pathogenic fungi, including Cryptococcus and Aspergillus species. Because the processed Prp8 carries out essential and non-redundant cellular functions, a Prp8 intein inhibitor is a mechanistically novel a...

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Bibliographic Details
Main Authors: Zhong Li, Bin Fu, Cathleen M. Green, Binbin Liu, Jing Zhang, Yuekun Lang, Sudha Chaturvedi, Marlene Belfort, Guojian Liao, Hongmin Li
Format: Article
Language:English
Published: Taylor & Francis Group 2019-01-01
Series:Emerging Microbes and Infections
Subjects:
Cisplatin
antifungal
Cryptococcus
Prp8 intein
mouse model
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2019.1625727

Internet

https://www.tandfonline.com/doi/10.1080/22221751.2019.1625727

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