The Tetrodotoxin Receptor of Voltage-Gated Sodium Channels—Perspectives from Interactions with μ-Conotoxins

The Tetrodotoxin Receptor of Voltage-Gated Sodium Channels—Perspectives from Interactions with μ-Conotoxins

Neurotoxin receptor site 1, in the outer vestibule of the conducting pore of voltage-gated sodium channels (VGSCs), was first functionally defined by its ability to bind the guanidinium-containing agents, tetrodotoxin (TTX) and saxitoxin (STX). Subsequent studies showed that peptide μ-conotoxins com...

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Bibliographic Details
Main Authors: Baldomero M. Olivera, Michael F. Sheets, Robert J. French, Doju Yoshikami
Format: Article
Language:English
Published: MDPI AG 2010-07-01
Series:Marine Drugs
Subjects:
guanidinium toxins
conopeptides
pore block
Online Access:http://www.mdpi.com/1660-3397/8/7/2153/

Internet

http://www.mdpi.com/1660-3397/8/7/2153/

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