Taurine reduces microglia activation in the brain of aged senescence-accelerated mice by increasing the level of TREM2

Abstract Alzheimer’s disease (AD), a chronic neurodegenerative disorder, is the leading cause of dementia. Over-activated microglia is related to amyloid-beta (Aβ) and phosphorylated tau (phospho-tau) accumulation in the AD brain. Taurine is an amino acid with multiple physiological functions includ...

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Những tác giả chính: Sharif Ahmed, Ning Ma, Jun Kawanokuchi, Keiya Matsuoka, Shinji Oikawa, Hatasu Kobayashi, Yusuke Hiraku, Mariko Murata
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Nature Portfolio 2024-03-01
Loạt:Scientific Reports
Truy cập trực tuyến:https://doi.org/10.1038/s41598-024-57973-4