Renal effects of the novel selective adenosine A1 receptor blocker SLV329 in experimental liver cirrhosis in rats.

Liver cirrhosis is often complicated by an impaired renal excretion of water and sodium. Diuretics tend to further deteriorate renal function. It is unknown whether chronic selective adenosine A(1) receptor blockade, via inhibition of the hepatorenal reflex and the tubuloglomerular feedback, might e...

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Bibliographic Details
Main Authors: Berthold Hocher, Susi Heiden, Karoline von Websky, Ayman M Arafat, Jan Rahnenführer, Markus Alter, Philipp Kalk, Dieter Ziegler, Yvan Fischer, Thiemo Pfab
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3053401?pdf=render