Statistical framework for calling allelic imbalance in high-throughput sequencing data

Statistical framework for calling allelic imbalance in high-throughput sequencing data

Abstract High-throughput sequencing facilitates large-scale studies of gene regulation and allows tracing the associations of individual genomic variants with changes in gene regulation and expression. Compared to classic association studies, the assessment of an allelic imbalance at heterozygous va...

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Bibliographic Details
Main Authors: Andrey Buyan, Georgy Meshcheryakov, Viacheslav Safronov, Sergey Abramov, Alexandr Boytsov, Vladimir Nozdrin, Eugene F. Baulin, Semyon Kolmykov, Jeff Vierstra, Fedor Kolpakov, Vsevolod J. Makeev, Ivan V. Kulakovskiy
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55513-2

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https://doi.org/10.1038/s41467-024-55513-2

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