In Vivo and In Vitro Enhanced Tumoricidal Effects of Metformin, Active Vitamin D<sub>3</sub>, and 5-Fluorouracil Triple Therapy against Colon Cancer by Modulating the PI3K/Akt/PTEN/mTOR Network

In Vivo and In Vitro Enhanced Tumoricidal Effects of Metformin, Active Vitamin D<sub>3</sub>, and 5-Fluorouracil Triple Therapy against Colon Cancer by Modulating the PI3K/Akt/PTEN/mTOR Network

Chemoresistance to 5-fluorouracil (5-FU) is common during colorectal cancer (CRC) treatment. This study measured the chemotherapeutic effects of 5-FU, active vitamin D<sub>3</sub> (VD<sub>3</sub>), and/or metformin single/dual/triple regimens as complementary/alternative ther...

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Bibliographic Details
Main Authors: Riyad Adnan Almaimani, Akhmed Aslam, Jawwad Ahmad, Mahmoud Zaki El-Readi, Mohamed E. El-Boshy, Abdelghany H. Abdelghany, Shakir Idris, Mai Alhadrami, Mohammad Althubiti, Hussain A. Almasmoum, Mazen M. Ghaith, Mohamed E. Elzubeir, Safaa Yehia Eid, Bassem Refaat
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
chemoresistance
calcitriol
metformin
cell cycle
apoptosis
phosphatidylinositol-3-kinase
Online Access:https://www.mdpi.com/2072-6694/14/6/1538

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https://www.mdpi.com/2072-6694/14/6/1538

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