IFNL4 and IFNL3 associated polymorphisms strongly influence the spontaneous IFN-alpha receptor-1 expression in HCV-infected patients.

IFNL4 and IFNL3 associated polymorphisms strongly influence the spontaneous IFN-alpha receptor-1 expression in HCV-infected patients.

Single-nucleotide polymorphism in IFNL3 gene (rs12979860) predicts spontaneous and therapy-induced HCV clearance. In a previous study from our group PBMC from patients with favourable rs12979860 genotype showed higher levels of IFNAR-1 mRNA. Recently, a dinucleotide polymorphism, ss469415590 (TT or...

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Bibliographic Details
Main Authors: Licia Bordi, Claudia Caglioti, Anna Rosa Garbuglia, Daniele Lapa, Concetta Castilletti, Chiara Taibi, Maria Rosaria Capobianchi, Eleonora Lalle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4326132?pdf=render

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http://europepmc.org/articles/PMC4326132?pdf=render

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