Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells

Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells

Recent evidence indicates that hemolysis in sickle cell disease (SCD) promotes inflammation via innate immune signaling through toll-like receptor 4 (TLR4). Free heme released by hemolyzed red blood cells can bind to myeloid differentiation factor-2 (MD-2) and activate TLR4 pro-inflammatory signalin...

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Bibliographic Details
Main Authors: Ping Zhang, Julia Nguyen, Fuad Abdulla, Alexander T. Nelson, Joan D. Beckman, Gregory M. Vercellotti, John D. Belcher
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
soluble MD-2
sickle cell disease
IL-8
endothelial cell
TLR4
heme
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.632709/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.632709/full

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