A γ-Glutamyl Transpeptidase (GGT)-Triggered Charge Reversal Drug-Delivery System for Cervical Cancer Treatment: In Vitro and In Vivo Investigation

A γ-Glutamyl Transpeptidase (GGT)-Triggered Charge Reversal Drug-Delivery System for Cervical Cancer Treatment: In Vitro and In Vivo Investigation

Neutral/negatively charged nanoparticles are beneficial to reduce plasma protein adsorption and prolong their blood circulation time, while positively charged nanoparticles easily transverse the blood vessel endothelium into a tumor and easily penetrate the depth of the tumor via transcytosis. Γ-Glu...

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Bibliographic Details
Main Authors: Jingxin Fu, Likang Lu, Manzhen Li, Yaoyao Guo, Meihua Han, Yifei Guo, Xiangtao Wang
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Pharmaceutics
Subjects:
γ-glutamyl transpeptidase
charge reversal
paclitaxel
cervical cancer
Online Access:https://www.mdpi.com/1999-4923/15/5/1335

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https://www.mdpi.com/1999-4923/15/5/1335

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