The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting

The short isoform of the host antiviral protein ZAP acts as an inhibitor of SARS-CoV-2 programmed ribosomal frameshifting

Programmed ribosomal frameshifting (PRF) occurs in many viruses including SARS-CoV-2 to allow the translation of multiple proteins from a single transcript. Here, the authors identify the human short isoform of the zinc-finger antiviral protein (ZAP-S) as a direct regulator of PRF in SARS-CoV-2 that...

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Bibliographic Details
Main Authors: Matthias M. Zimmer, Anuja Kibe, Ulfert Rand, Lukas Pekarek, Liqing Ye, Stefan Buck, Redmond P. Smyth, Luka Cicin-Sain, Neva Caliskan
Format: Article
Language:English
Published: Nature Portfolio 2021-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-27431-0

Internet

https://doi.org/10.1038/s41467-021-27431-0

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