ACAT1/SOAT1 Blockade Suppresses LPS-Mediated Neuroinflammation by Modulating the Fate of Toll-like Receptor 4 in Microglia

ACAT1/SOAT1 Blockade Suppresses LPS-Mediated Neuroinflammation by Modulating the Fate of Toll-like Receptor 4 in Microglia

Cholesterol is stored as cholesteryl esters by the enzymes acyl-CoA:cholesterol acyltransferases/sterol O:acyltransferases (ACATs/SOATs). ACAT1 blockade (A1B) ameliorates the pro-inflammatory responses of macrophages to lipopolysaccharides (LPS) and cholesterol loading. However, the mediators involv...

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Bibliographic Details
Main Authors: Haibo Li, Thao N. Huynh, Michael Tran Duong, James G. Gow, Catherine C. Y. Chang, Ta Yuan Chang
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
cholesterol
cholesteryl esters
acyl-CoA:cholesterol acyltransferase
sterol O-acyltransferase
ACAT inhibitor
lipid rafts
Online Access:https://www.mdpi.com/1422-0067/24/6/5616

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https://www.mdpi.com/1422-0067/24/6/5616

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