Genome-wide CRISPR screen identifies GNE as a key host factor that promotes influenza A virus adsorption and endocytosis

Genome-wide CRISPR screen identifies GNE as a key host factor that promotes influenza A virus adsorption and endocytosis

ABSTRACT Replication of influenza A virus (IAV) is highly reliant on host cell function, and to identify the key host factor required in the influenza A virus life cycle, a genome-wide CRISPR/Cas9 knockout (KO) screen was conducted in A549 cells infected by H1N1 influenza virus. The results showed t...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Tianxin Ma, Shiqi Niu, Zihua Wu, Shenghui Pan, Chenyang Wang, Xiaona Shi, Minghao Yan, Bangfeng Xu, Xingpo Liu, Luzhao Li, Dawei Yan, Qiaoyang Teng, Chunxiu Yuan, Xue Pan, Zhifei Zhang, Hoang Minh Duc, Zejun Li, Qinfang Liu
Format: Artykuł
Język:English
Wydane: American Society for Microbiology 2023-12-01
Seria:Microbiology Spectrum
Hasła przedmiotowe:
influenza A virus
GNE
sialic acid
adsorption
Dostęp online:https://journals.asm.org/doi/10.1128/spectrum.01643-23

Internet

https://journals.asm.org/doi/10.1128/spectrum.01643-23

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