Suicide-Gene-Modified Extracellular Vesicles of Human Primary Uveal Melanoma in Future Therapies

Suicide-Gene-Modified Extracellular Vesicles of Human Primary Uveal Melanoma in Future Therapies

Extracellular vesicles secreted from uveal melanoma (UM) cells are involved in the establishment of the premetastatic niche and display transforming potential for the formation of metastases, preferentially in the liver. In this study, we cultivated human primary UM cells and uveal melanoma-associat...

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Bibliographic Details
Main Authors: Jana Jakubechova, Bozena Smolkova, Alena Furdova, Lucia Demkova, Ursula Altanerova, Andreas Nicodemou, Tatiana Zeleznikova, Daniela Klimova, Cestmir Altaner
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
primary uveal melanoma
transduction with suicide gene
therapeutic extracellular vesicles
gene-directed enzyme prodrug therapy
Online Access:https://www.mdpi.com/1422-0067/24/16/12957

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https://www.mdpi.com/1422-0067/24/16/12957

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