Zileuton, a 5-Lipoxygenase Inhibitor, Attenuates Haemolysate-Induced BV-2 Cell Activation by Suppressing the MyD88/NF-κB Pathway

Zileuton, a 5-Lipoxygenase Inhibitor, Attenuates Haemolysate-Induced BV-2 Cell Activation by Suppressing the MyD88/NF-κB Pathway

M1 microglia induce neuroinflammation-related neuronal death in animal models of spontaneous subarachnoid haemorrhage. Zileuton is a 5-lipoxygenase inhibitor that reduces the levels of downstream pro-inflammatory cytokines. This study aimed to investigate whether zileuton inhibits microglial activat...

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Bibliographic Details
Main Authors: Hui-Yuan Su, Yi-Cheng Tsai, Hung-Pei Tsai, Chih-Lung Lin
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
5-lipoxygenase
BV-2 cells
microglia
subarachnoid haemorrhage
zileuton
Online Access:https://www.mdpi.com/1422-0067/23/9/4910

Internet

https://www.mdpi.com/1422-0067/23/9/4910

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