Tyrosine phosphatase PTPN11/SHP2 in solid tumors - bull’s eye for targeted therapy?

Tyrosine phosphatase PTPN11/SHP2 in solid tumors - bull’s eye for targeted therapy?

Encoded by PTPN11, the Src-homology 2 domain-containing phosphatase 2 (SHP2) integrates signals from various membrane-bound receptors such as receptor tyrosine kinases (RTKs), cytokine and integrin receptors and thereby promotes cell survival and proliferation. Activating mutations in the PTPN11 gen...

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Bibliographic Details
Main Authors: Xun Chen, Steffen Johannes Keller, Philipp Hafner, Asma Y. Alrawashdeh, Thomas Yul Avery, Johana Norona, Jinxue Zhou, Dietrich Alexander Ruess
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
SHP2
solid tumor
signaling pathway
tumor microenvironment
immune microenvironment
therapy resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1340726/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1340726/full

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