Tyrosine phosphatase PTPN11/SHP2 in solid tumors - bull’s eye for targeted therapy?

Tyrosine phosphatase PTPN11/SHP2 in solid tumors - bull’s eye for targeted therapy?

Encoded by PTPN11, the Src-homology 2 domain-containing phosphatase 2 (SHP2) integrates signals from various membrane-bound receptors such as receptor tyrosine kinases (RTKs), cytokine and integrin receptors and thereby promotes cell survival and proliferation. Activating mutations in the PTPN11 gen...

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Bibliographic Details
Main Authors:	Xun Chen, Steffen Johannes Keller, Philipp Hafner, Asma Y. Alrawashdeh, Thomas Yul Avery, Johana Norona, Jinxue Zhou, Dietrich Alexander Ruess
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-03-01
Series:	Frontiers in Immunology
Subjects:	SHP2 solid tumor signaling pathway tumor microenvironment immune microenvironment therapy resistance
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1340726/full

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