Parental smoking exposure before and during pregnancy and offspring attention-deficit/hyperactivity disorder risk: A Chinese child and adolescent cohort study
BackgroundPrevious studies revealed that maternal smoking exposure during pregnancy was an essential risk factor for offspring developing attention-deficit/hyperactivity disorder (ADHD). The impact of paternal smoking exposure 1 year before pregnancy on offspring ADHD risk is still unclear.MethodsTh...
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| Format: | Article |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1017046/full |
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| author | Dong Liu Yaping Ren Tianfeng Wu Huiping Shen Peijing Yan Yu Meng Qianlong Zhang Jun Zhang Pinqing Bai Jian Zhao |
| author_facet | Dong Liu Yaping Ren Tianfeng Wu Huiping Shen Peijing Yan Yu Meng Qianlong Zhang Jun Zhang Pinqing Bai Jian Zhao |
| author_sort | Dong Liu |
| collection | DOAJ |
| description | BackgroundPrevious studies revealed that maternal smoking exposure during pregnancy was an essential risk factor for offspring developing attention-deficit/hyperactivity disorder (ADHD). The impact of paternal smoking exposure 1 year before pregnancy on offspring ADHD risk is still unclear.MethodsThe present study included 2,477 school-age children and their parents from the Shanghai Child and Adolescent Health Cohort who had complete data for offspring ADHD diagnosis and parents' smoking exposure before and during pregnancy information. A multivariate logistic regression model and Firth's logistic regression model were used to determine the associations of paternal smoking and parental smoke exposure patterns before and during pregnancy with offspring ADHD risk.ResultsChildren whose fathers smoked before pregnancy had a higher risk of developing ADHD [odds ratio (OR) = 2.59, 95% confidence interval (CI): 1.35–4.98] compared to those whose fathers had never been exposed to smoking. Similarly, parents who were exposed to smoking or second-hand smoke before pregnancy had 1.96 times (OR = 1.96, 95% CI: 1.19–3.22) more likely to have offspring with ADHD. Moreover, children whose parents were exposed to smoking both before and during pregnancy were 2.01 times (OR = 2.01, 95% CI: 1.29–3.12) more likely to develop ADHD.ConclusionPaternal smoking before pregnancy and parental smoking exposure 1 year ahead of and throughout pregnancy were all risk factors for offspring developing ADHD. |
| first_indexed | 2024-04-11T17:03:38Z |
| format | Article |
| id | doaj.art-80a97bfc96a34bb69645dda50fd7fa26 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-11T17:03:38Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-80a97bfc96a34bb69645dda50fd7fa262022-12-22T04:13:05ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-10-011010.3389/fpubh.2022.10170461017046Parental smoking exposure before and during pregnancy and offspring attention-deficit/hyperactivity disorder risk: A Chinese child and adolescent cohort studyDong Liu0Yaping Ren1Tianfeng Wu2Huiping Shen3Peijing Yan4Yu Meng5Qianlong Zhang6Jun Zhang7Pinqing Bai8Jian Zhao9The Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of School Health, Food Nutrition and Safety, Pudong New Area Center for Disease Control and Prevention, Shanghai, ChinaDepartment of School Health, Food Nutrition and Safety, Pudong New Area Center for Disease Control and Prevention, Shanghai, ChinaDepartment of School Health, Food Nutrition and Safety, Pudong New Area Center for Disease Control and Prevention, Shanghai, ChinaWest China School of Public Health, Sichuan University, Chengdu, ChinaThe Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaThe Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaThe Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of School Health, Food Nutrition and Safety, Pudong New Area Center for Disease Control and Prevention, Shanghai, ChinaThe Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaBackgroundPrevious studies revealed that maternal smoking exposure during pregnancy was an essential risk factor for offspring developing attention-deficit/hyperactivity disorder (ADHD). The impact of paternal smoking exposure 1 year before pregnancy on offspring ADHD risk is still unclear.MethodsThe present study included 2,477 school-age children and their parents from the Shanghai Child and Adolescent Health Cohort who had complete data for offspring ADHD diagnosis and parents' smoking exposure before and during pregnancy information. A multivariate logistic regression model and Firth's logistic regression model were used to determine the associations of paternal smoking and parental smoke exposure patterns before and during pregnancy with offspring ADHD risk.ResultsChildren whose fathers smoked before pregnancy had a higher risk of developing ADHD [odds ratio (OR) = 2.59, 95% confidence interval (CI): 1.35–4.98] compared to those whose fathers had never been exposed to smoking. Similarly, parents who were exposed to smoking or second-hand smoke before pregnancy had 1.96 times (OR = 1.96, 95% CI: 1.19–3.22) more likely to have offspring with ADHD. Moreover, children whose parents were exposed to smoking both before and during pregnancy were 2.01 times (OR = 2.01, 95% CI: 1.29–3.12) more likely to develop ADHD.ConclusionPaternal smoking before pregnancy and parental smoking exposure 1 year ahead of and throughout pregnancy were all risk factors for offspring developing ADHD.https://www.frontiersin.org/articles/10.3389/fpubh.2022.1017046/fullattention-deficit/hyperactivity disorder (ADHD)paternal smokingsecond-hand smoke (SHS) exposurepregnancy smoking cessationparental smoking |
| spellingShingle | Dong Liu Yaping Ren Tianfeng Wu Huiping Shen Peijing Yan Yu Meng Qianlong Zhang Jun Zhang Pinqing Bai Jian Zhao Parental smoking exposure before and during pregnancy and offspring attention-deficit/hyperactivity disorder risk: A Chinese child and adolescent cohort study Frontiers in Public Health attention-deficit/hyperactivity disorder (ADHD) paternal smoking second-hand smoke (SHS) exposure pregnancy smoking cessation parental smoking |
| title | Parental smoking exposure before and during pregnancy and offspring attention-deficit/hyperactivity disorder risk: A Chinese child and adolescent cohort study |
| title_full | Parental smoking exposure before and during pregnancy and offspring attention-deficit/hyperactivity disorder risk: A Chinese child and adolescent cohort study |
| title_fullStr | Parental smoking exposure before and during pregnancy and offspring attention-deficit/hyperactivity disorder risk: A Chinese child and adolescent cohort study |
| title_full_unstemmed | Parental smoking exposure before and during pregnancy and offspring attention-deficit/hyperactivity disorder risk: A Chinese child and adolescent cohort study |
| title_short | Parental smoking exposure before and during pregnancy and offspring attention-deficit/hyperactivity disorder risk: A Chinese child and adolescent cohort study |
| title_sort | parental smoking exposure before and during pregnancy and offspring attention deficit hyperactivity disorder risk a chinese child and adolescent cohort study |
| topic | attention-deficit/hyperactivity disorder (ADHD) paternal smoking second-hand smoke (SHS) exposure pregnancy smoking cessation parental smoking |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.1017046/full |
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